featured client projects
hybridon
The state-of-the-art laboratories were the first major installation on the eastern seaboard focusing on the new anti-sense technology. DNA synthesis and analysis are key components and require attention to sensitive specialized functions.
The Hybridon Building at 620 Memorial Drive in Cambridge (now owned by Pfizer) is an excellent example of the adaptive re-use and rehabilitation of significant buildings along the Charles River. Once occupied by tire manufacturers supplying the adjacent Ford Motor Company building, the new facility was totally rebuilt on the existing structural frame, and two new floors added bringing for a total of 90,000 square feet of labs and offices.
Unisyn Technologies
As the biotechnology world continues to develop new products and techniques, design professionals have to respond with more demanding design solutions to house them. In this case, a specialized cGMP production facility was the answer.
UNISYN developed a “better mouse trap” in the world of hollow fiber cell culture technology. Using novel scaling techniques and unique media concepts, UNISYN developed ultra-compact benchtop cell growth chambers that significantly reduce the space and service needs in producing large quantities of monoclonal antibodies.
John Rafuse completed the design of UNISYN’s multi-suite cGMP production facilitiy at the Massachusetts Biotechnology Research Park. The facility includes raw material quarantine and storage areas, isolation chambers for initial cell line quarantine and testing, production rooms for growing the cell lines, purification areas and aseptic fill room. Q/C labs, R&D labs, office space and shipping receiving spaces complete the plan. The design solution developed passed rigorous review by both GMP consultants and the FDA on the first round. Flow diagrams and "basis of design rationale”, developed as part of the design process, expedited the approval process.
UNISYN developed a “better mouse trap” in the world of hollow fiber cell culture technology. Using novel scaling techniques and unique media concepts, UNISYN developed ultra-compact benchtop cell growth chambers that significantly reduce the space and service needs in producing large quantities of monoclonal antibodies.
John Rafuse completed the design of UNISYN’s multi-suite cGMP production facilitiy at the Massachusetts Biotechnology Research Park. The facility includes raw material quarantine and storage areas, isolation chambers for initial cell line quarantine and testing, production rooms for growing the cell lines, purification areas and aseptic fill room. Q/C labs, R&D labs, office space and shipping receiving spaces complete the plan. The design solution developed passed rigorous review by both GMP consultants and the FDA on the first round. Flow diagrams and "basis of design rationale”, developed as part of the design process, expedited the approval process.
tolerRx
TolerRx is a shining example of collaboration between designers and client, focusing on new ways to solve typical laboratory situations. John Rafuse and TolerRx worked with a west coast design firm to create lab space that functionally met the needs of the science, while "breaking the mold" for interior design concepts.
The 20,000 square foot space in Cambridge, MA included biology laboratories, clean cell culture and down stream processing areas, a 4000 sf animal care facility, full laboratory support spaces and corporate offices. Extensive use of color, form, natural light and glass within the facility make the space unique yet functional, allowing the researchers to feel they can achieve their goals in a space that invites creativity and interaction between all employees, both corporate and scientific.
The 20,000 square foot space in Cambridge, MA included biology laboratories, clean cell culture and down stream processing areas, a 4000 sf animal care facility, full laboratory support spaces and corporate offices. Extensive use of color, form, natural light and glass within the facility make the space unique yet functional, allowing the researchers to feel they can achieve their goals in a space that invites creativity and interaction between all employees, both corporate and scientific.
Origenix
Origenix, a spinoff from Hybridon of Cambridge, chose Montreal for their 20,000 square foot lab and office facility. Montreal is a well established epicenter for biotechnology and pharmaceutical companies.
Origenix's proprietary science technology, closely related to anti-sense and nucleic acid chemistry, created the need for demanding combinatorial and medicinal chemistry lab spaces, cell culture, NMR and analytical spaces.
The Biotecture™ design solution included a new building structure to house the headquarters for both the science and corporate components of the company.
Origenix's proprietary science technology, closely related to anti-sense and nucleic acid chemistry, created the need for demanding combinatorial and medicinal chemistry lab spaces, cell culture, NMR and analytical spaces.
The Biotecture™ design solution included a new building structure to house the headquarters for both the science and corporate components of the company.