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                                                                 approach to the profession

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John Rafuse AIA has maintained a 33-year commitment to architecturally significant buildings specializing in the design demands of corporate and technology facilities. His work includes office buildings, laboratories, R&D, and production facilities. His clients include many well-known corporate institutions, biotechnology companies and pharmaceutical companies.

He is a proactive and creative architect that is totally comfortable in the building world and scientific environment. These communities appreciate his ability to innovate and to implement practical, usable designs. His forthright, proactive style and his ability to listen and respond quickly, have enabled him to win the trust and confidence of his clients.

John places most emphasis on fully understanding his client’s activities. He is thoroughly versed in building and office technology, laboratory operations and production processes. Furthermore, with an education at Rensselaer Polytechnic Institute, a lifetime of immersion in the construction community, and nearly all of his career in an A/E environment, he can accurately envision and thoroughly understand his design solutions, He believes intelligent design comes from a fundamental understanding of the client’s daily activities in today’s environment, anticipating the environment of the future.

John has been actively working in lab consulting and building design for the Northeast Biotechnology community for the last 30 years and has designed well over 
2 million square feet of life science related biotecture™ space.

For a downloadable copy of John's resume, click here

representative projects



Lab & Office projects


A123 Systems, Inc.

Waltham and Watertown MA
Original 10,000 sf lab and office project
Follow on additions and modifications
New Labs and Production Facilities - 25,000 sf

Alpha-Beta Technologies
- cGMP Pilot Plant Design
- R & D Laboratories

Aveo Pharmaceuticals (formerly GenPath)
lab and office facility - 50,000 sf
state of the art animal care facility - 10,000 sf

Massachusetts Biotechnology Research Park
- Complete Laboratory/Office Fit-out
One Biotech 75,000 sf
- Complete Laboratory/Office Fit-out
Two Biotech 85,000 sf
- Complete Laboratory/Office Fit-out
Four Biotech 95,000 sf

Aquila Biopharmaceuticals
- cGMP Pilot Production Suite
- R & D Laboratory and Office Facility
- 2,000 sf Animal Care Facility

AutoImmune 
- Laboratory Renovations

BioScience Enterprise Incubator Facility
Halifax, Nova Scotia
- 27,000 sf Lab and Office Facility

CytoTherapeutics Inc.
- Aseptic Pilot Process Plant (8,000 sf)
- R & D Facility 24, 000 sf 
- Animal Care Facility 6,000 sf

DuPont Merck 
- QC Lab Renovations - 9,000 sf

Fort Washington Research Center
- Building Renovations for Biotechnology Occupancy 100,000 sf

Pharm-Eco
- R & D Laboratory Planning - 8,000 sf

Geltex
- R & D Laboratory Planning - 12,000 sf
Hybridon
- 95,000 sf Complete Building Renovations
- Executive Headquarters Offices
- R & D Laboratories

IDEXX Laboratories
Offices, Labs, Production, Mfg - 125,000 sf

Joule Unlimited
Bedford, MALab and production facilities - 10,000 sf 

Leukosite
Lab Expansions
30,000 sf Laboratory and Office

MethylGene
Montreal, Quebec, Canada
- 9,000 sf Laboratory and Office Facility 1997
- 9,000 sf Lab and Office Expansion 2000
- 2,000 sf Lab and Office Expansion 2002






Millipore Waters Chromatography
Chemical Products Division
- Laboratory Programming/Planning

Neptune Pharmaceuticals
- Laboratories and Executive Offices - 6,000 sf

Origenix
Montreal, Quebec, Canada
- 20,000 sf Laboratory and Office Facility 

Oravax 
- Animal Care Facilities
- Special Formulations Laboratory Design
- cGMP Pilot Room
- Lab/Office Planning - 40,000 sf

Phytera
- R & D Laboratories - 2,000 sf

Polaroid 
- 11X Coating Facility and Manufacturing Plant - 250,000 sf
- Class 100k Clean Room - 40,000 sf

Quantum Biotechnology
Montreal Canada
- 10,000 sf Laboratory and Office Facility

TolerRx 
- R & D Laboratories - 25,000 sf
- Animal Care Facilities - 5,000 sf

V.I. Technologies
- R & D Laboratories 2000 - 30,000 sf

Zycos
- R & D Laboratories - 18,000 sf
- R & D Laboratories Expansion 2001 - 6,000 sf

Production Facility Projects 

Unisyn Technologies
- GMP Production Facility - 6,000 sf

DuPont Merck
- cGMP Production Facility - 5,000 sf

Telor Ophthalmic Pharmaceutical
- cGMP Manufacturing Suite
- Laboratories and Executive Offices - 25,000 sf

Nitinol Medical Technologies
- cGMP Manufacturing Facility, R & D Laboratories - 25,000 sf 

University of Massachusetts - Program for Molecular Medicine
- Animal Care Facility and Microbiology, NMR, Optics, BSL-3 Labs 
45,000 sf 

University of Rhode Island Coastal Institute
Kingston, RI
- Animal Care Facility and Multi-use Laboratory Design (AAALAC/USDA)
- Complete Laboratory Building Design - 80,000 sf

Vertex Pharmaceuticals - 60,000 sf
- Animal Care Facility
- R & D Laboratories
- Executive Offices

W. R. Grace
Grace Construction Products
- Lab/Office Renovations - 30,000 sf
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